Publications (lab members underlined)

For the most up-to-date list, search for us on Pubmed.




72. Sessions, A.O., Kaushik, G., Parker, S., Raedschelders, K., Duong, J.T., Bodmer, R., Van Eyk, J.E., and Engler, A.J. (2017) "Extracellular Matrix Downregulation in the Drosophila Heart Preserves Contractile Function and Improves Lifespan." Matrix Biol. (in press; DOI: 10.1016/j.matbio.2016.10.008) [paper]



71. Thomas, K.A., Gibbons, M.C., Lane, J.G., Singh, A., Ward, S.R., and Engler, A.J. (2017) "Rotator cuff tear state modulates self-renewal and differentiation capacity of skeletal muscle progenitor cells." J Ortho Res (in press; DOI: 10.1002/jor.23453) [paper]



70. Fuhrmann, A., Banisadr, A., Beri, P., Tlsty, T.D., and Engler, A.J. (2017) "Metastatic State of Cancer Cells may be indicated by Adhesion Strength." Biophys J 112(4): 736-745. [paper] Media Coverage: [UCSD Press Release] [BBC News] [EurekAlert!] [eCancer Press Release] [Rocket News] [Guernsey Press] [Health Medicine Network] [ABC Health (Spanish)] [BioPortfolio] [Cancer Research UK]



69. Gibbons, M.C., Singh, A., Anakwenze, O., Cheng, T., Pomerantz, M.D., Schenk, S., Engler, A.J., and Ward, S.R. (2017) "Histological Findings in Chronically Torn Human Rotator Cuff Muscle: Evidence of Degeneration, Regeneration and Remodeling." J Bone Joint Surg Am 99(3): 190-199. [paper]



68. Blice-Baum, A.C., Zambon, A.C., Kaushik, G., Viswanathan, M.C., Engler, A.J., Bodmer, R., and Cammarato, A. (2017) "Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline.” Aging Cell 16(1): 93-103. [paper]



67. Gibbons, M.C., Sato, E.J., Bachasson, D., Cheng, T., Azimi, H., Schenk, S., Engler, A.J., Singh, A., and Ward, S.R. (2016) "Muscle Architectural Changes After Massive Human Rotator Cuff Tear." J Ortho Res 34(12):2089-2095. [paper]



66. Holle, A.W., McIntyre, A.J., Kehe, J., Wijesekara, P., Young, J.L., Vincent, L.G., and Engler, A.J., (2016) "High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation." Integrative Biology 8, 1049–1058. [paper]



65. Session, A.O., and Engler, A.J., (2016) "Mechanical Regulation of Cardiac Aging in Model Systems." Circ Res 118: 1553-1562.[paper]



64. Zhang, Z.-N., Freitas, B.C., Qian, H., Lux, J., Acab, A.J., Trujillo, C., Herai, R., Nguyen Huu, V.A., Wen, J.H., Joshi-Barr, S., Karpiak, J.V, Engler, A.J., Fu, X.-D., Muotri, A.R., and Almutairi, A. (2016) "Layered hydrogels accelerate iPSC-derived neuronal maturation and reveal migration defects in Rett syndrome." Proc Nat Acad Sci USA 113(12):3185-90.[paper]



63. Ondeck, M., and Engler, A.J. (2016) "Mechanical Characterization of a Dynamic and Tunable Methacrylated Hyaluronic Acid Hydrogel." J Biotech Eng 138(2):021003-021003-6. [paper]



62. Happe, C.L., and Engler, A.J. (2016) "Mechanical Forces Reshape Differentiation Cues that Guide Cardiomyogenesis." Circ Res 118(2): 296-310. [paper]



61. Wen, J.H., Choi, O., Taylor-Weiner, H., Fuhrmann, A., Karpiak, J.V. Almutairi, A., and Engler, A.J. (2015) "Haptotaxis is cell type specific and limited by substrate adhesiveness." Cell Mol Bioeng 8(4): 530-542.[paper]



60. Meyer, G.A., Gibbons, M., Sato, E., Lane, J.G., Ward, S.R., and Engler, A.J. (2015) "Epimuscular Fat in the Human Rotator Cuff is a Novel Beige Depot" Stem Cells Trans Med 4(7): 764-74.[paper]



59. Wu, H., Lee, J., Vincent, L.G., Wang, Q., Gu, M., Lan, F., Churko, J.M., Sallam, K.I., Matsa, E., Sharma, A., Gold, J.D., Engler, A.J., Xiang, Y.K., Bers, D.M., and Wu, J.C. (2015) "Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised Beta-Adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy." Cell Stem Cell 7(1): 89-100. [paper] Media Coverage: [Science Daily] [Stanford University Press Release]



58. Fuhrmann, A., and Engler, A.J. (2015) "The Cytoskeleton Regulates Cell Attachment Strength" Biophys J 109(1): 57-65.[paper]

57. Kaushik, G., Spenlehauer, A., Sessions, A.O., Trujillo, A.S., Fuhrmann, A., Fu, Z., Venkatraman, V., Pohl, D., Tuler, J., Wang, M., Lakatta, E.G, Ocorr, K., Bodmer, R., Bernstein, S.I., Van Eyk, J.E., Cammarato, A., and Engler, A.J. (2015) "Vinculin-network mediated Cytoskeletal Remodeling and Regulation of Contractile Function in Aging Myocardium." Science Trans Med 292: 292ra99. [paper] Media Coverage: [JHU Press Release] [UC San Diego Press Release] [San Diego Union-Tribune] [Medical Xpress] [GEN News] [Yahoo News] [Hindustan Times]



56. Hribar, K.C., Finlay, D., Ma, X., Qu, X., Ondeck, M. G., Chung, P.H., Zanella, F., Engler, A.J., Sheikh, F., Vuori, K., Chen, S. (2015) "Nonlinear 3D projection printing of concave hydrogel microstructures for long-term multicellular spheroid and embryoid body culture." Lab-on-a-Chip 15(11): 2412-2418. [paper]



55. Taylor-Weiner, H., Ravi, N., and Engler, A.J. (2015) “Traction Forces mediated by Integrin Signaling are Necessary for Definitive Endoderm Specification." J Cell Sci 128(10): 1961-1968. [paper]



54. Jun, I., Lee, Y.B., Choi, Y.S., Engler, A.J., Park, H., Shin, H. (2015) "Transfer stamping of human mesenchymal stem cell patches using thermally expandable hydrogels with tunable cell-adhesive properties." Biomaterials 54:44-54. [paper]



53. Wei, S.C., Fattet, L., Tsai, J.H., Guo, Y., Pai, V.H., Majecki, H.E., Chen, A.C., Sah, R.L., Taylor, S.S., Engler, A.J., and Yang J. (2015) "Matrix stiffness drives Epithelial-Mesenchymal Transition and tumor metastasis through a Twist1-G3BP2 mechanotransduction pathway." Nature Cell Biology 17(5): 678-688. [paper] Media Coverage: [UCSD Press Release]



52. Viswanathan, P.,* Ondeck, M.G.,* Chirasatitsin, S., Nghamkham, K., Reilly, G.C., Engler, A.J., and Battaglia, G. (2015) "3D Surface Topology Guides Stem Cell Adhesion and Differentiation." Biomaterials 52:140-147. *co-first authors [paper]



51. Meyer, G.A., Farris, A., Sato, E., Gibbons, M., Lane, J.G., Ward, S.R. and Engler, A.J. (2015) "Muscle Progenitor Cell Regenerative Capacity in the Torn Rotator Cuff." J Ortho Res 33(3): 421-429. [paper] [Journal Cover]



50. Fuhrmann, A. and Engler, A.J. (2015) "Acute Shear Stress Dictates Adherent Cell Remodeling and Verifies Shear Profile of Spinning Disc Assays." Phys Biol 12(1): 016011. [paper]



49. Thomas, K.A., Engler, A.J., and Meyer, G.A. (2015) "Extracellular Matrix Regulation In The Muscle Satellite Cell Niche." Connect Tissue Res 56(1): 1-8. [paper]



48. Wen, J.H.*, Vincent, L.G.*, Fuhrmann, A., Choi, Y.S., Hribar, K.C., Taylor-Weiner, H., Chen, S., and Engler, A.J. (2014) "Interplay of matrix stiffness and protein tethering in stem cell differentiation." Nature Materials 13(10): 979-987. *co-first authors [paper] Media Coverage: [UCSD Press Release] [eurekalert] [Phys.org]



47. Young, J.L., Kretchmeyer, K., Ondeck, M. G., Zambon, A.C., and Engler, A.J. (2014) "Mechanosensitive Kinases Regulate Stiffness-Induced Cardiomyogenesis." Sci Reports 4: 6425. [paper]



46. Hribar, K.C., Choi, Y.S., Ondeck, M., Engler, A.J., and Chen, S. (2014) "Digital Plasmonic Patterning of Hydrogels" Adv Funct Mat 24(31): 4922-4926. [paper]



45. Fuhrmann, A., Li, J., Chien, S., and Engler, A.J. (2014) "Cation Type Specific Cell Remodeling Regulates Attachment Strength"" PLOS ONE 9(7): e102424. [paper]



44. Murphy, W.L., McDevitt, T.C., and Engler, A.J. (2014) "Materials as Intrinsic Regulators" Nature Materials 13(6): 547-557. [paper]



43. Nishimura, M., Kumsta, C., Kaushik, G., Ding, Y., Bisharat-Kernizan, J., Cammarato, A., Ross, R.S., Engler, A.J., Bodmer, R., Hansen, M., and Ocorr, K.(2014) "Dual role of Integrin and Integrin Linked Kinase in cardiac aging and integrity" Aging Cell 13(3): 431-440. [paper]



42. Viswanathan, M.C., Kaushik, G., Engler, A.J., Lehman, W., and Cammarato, A. (2014) "A Drosophila model of diastolic dysfunction and cardiomyopathy based on impaired troponin function" Circ Research 114:e6-e17. [paper]



41. Holle, A.W., Tang, X., Vijayraghavan, D., Vincent, L.G., Fuhrmann, A., Choi, Y.S., del Alamo, J.C., and Engler, A.J., (2013) "In Situ Mechanotransduction via Vinculin Regulates Stem Cell Myogenesis" Stem Cells 31(11): 2467-77 [paper]



40. Rao, N., Grover, G.N., Vincent, L.G., Evans, S.C., Choi, Y.S., Spencer, K.H., Hui, E.E., Engler, A.J., and Christman, K.L. (2013) "A co-culture device with a tunable stiffness to understand combinatorial cell-cell and cell-matrix interactions" Integrative Biology 5(11): 1344 - 1354 [paper]



39. Taylor-Weiner, H., Schwarzbauer, J.E., and Engler, A.J., (2013) "Defined Extracellular Matrix Components are Necessary for Definitive Endoderm Induction" Stem Cells 31(10): 2084-94 [paper]



38. Young, D.A., Choi, Y.S., Engler, A.J., and Christman, K.L. (2013) "Mimicking the stiffness of adipose tissue stimulates adipogenesis of adult adipose-derived stem cells" Biomaterials 34(34): 8581-8588 [paper]



37. Kiang, J.D., Wen, J.H., del Alamo, J.C., and Engler, A.J. (2013) "Dynamic and Reversible Surface Topography Influences Cell Morphology" J Biomed Mat Res A 101A(8): 2313-2321 [paper]



36. Young, J.L., Tuler, J., Braden, R., Schup-Magoffin, P., Schaefer, J., Kretchmer, K., Christman, K. L., and Engler, A.J. (2013) "Thiolated hyaluronic acid hydrogels have limited myocardial Compatibility" Acta Biomaterialia 9(7): 7151–7157 [paper]



35. Vincent, L.G., Choi, Y.S., Alonso-Latorre, B., del Alamo, J.C., and Engler, A.J. (2013) "Mesenchymal Stem Cell Durotaxis Depends on Substrate Stiffness Gradient Strength" Biotechnology J 8(4): 472-84. [paper]



34. Joshi-Barr, S., Karpiak, J.V., Ner, Y., Wen, J.H., Engler, A.J., and Almutairi, A. (2013) "Density Gradient Multilayered Polymerization (DGMP): a novel technique for creating multi-compartment, customizable scaffolds for tissue engineering." J Vis Exp 72: e50018. [paper]



33. Viswanathan, P.,* Chirasatitsin, S.,* Ngamkham, K., Engler, A.J.#, and Battaglia, G.# (2012) "Cell instructive microporous scaffolds through interface engineering" J Am Chem Soc 134(49): 20103-20109 *co-first authors #co-corresponding authors [paper] Media Coverage: [HFSP Press Release] [UCSD Press Release] [Sheffield Press Release] [Nature - Research Highlight] [The A to Z of Nanotechnology - Interview]



32. Kshitiz, K., Park, J. S., Kim, P., Helen, W., Engler, A.J., Levchenko, A., Kim, D-H. (2012) "Control of stem cell fate and function by engineering physical microenvironments." Integrative Biology 4(9): 1008-1018 [paper]



31. Choi, Y. S., Vincent, L. V., Lee, A. R., Kretchmer, K. C., Chirasatitsin, S., Dobke, M., and Engler, A.J. (2012) "The alignment and fusion assembly of adipose-derived stem cells on mechanically patterned matrices." Biomaterials 33(29): 6943-6951 [paper]



30. Kaushik, G., Zambon, A., Fuhrmann, A., Bernstein, S.I., Bodmer, R., Engler, A.J., and Cammarato, A. (2012) "Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic function." J Cell Mol Med 16(8): 1656-1662 [paper]



29. Choi, Y.S., Vincent, L.G., Lee, A.R., Dobke, M.A., and Engler, A.J. (2012) "Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells." Biomaterials 33(8): 2482-2491 [paper] Media Coverage: [Mesenchymal Cell News] [UCSD Press Release]



28. Kaushik, G., Fuhrmann, A., Cammarato, A., and Engler, A.J., (2011) "Indentation Analysis of Soft Bilayers: In Situ Measurements of Drosophila Myocardial Stiffness" Biophys J 101(11): 2629-2637 [paper] [Indentation Analysis Software for Soft Multilayered Materials]



27. Battaglia G., LoPresti C., Massignani M., Warren N.J., Madsen J., Forster S., Vasilev C., Hobbs J.K., Armes S.P., Chirasatitsin S., and Engler A.J., (2011) "Wet nanoscale imaging and testing of polymersomes" Small 7(14):2010-5 [paper]



26. Holle, A.W. and Engler, A.J., (2011) "More Than a Feeling: Discovering, Understanding, and Influencing Mechanosensing Pathways" Curr Opin Biotech 22(5): 648-54 [paper]



25. LoPresti, C., Massignani, M., Fernyhough, C., Blanazs, A., Ryan, A., Madsen, J., Warren, N., Armes, S., Chirasatitsin, S., Engler, A.J., and Battaglia, G. (2011) "Controlling Polymersomes Surface Topology at the Nanoscale by Membrane Confined Polymer/Polymer Phase Separation" ACS Nano 5(3): 1775-84 [paper]



24. Tse, J.R. and Engler, A.J. (2011) "Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate" PLoS ONE 6(1): e1597 [paper]



23. Young, J.L. and Engler, A.J. (2011) "Hydrogels with Time-Dependent Mechanical Properties Enhance Cardiomyocyte Differentiation In Vitro" Biomaterials 32(4): 1002-1009 [paper] Media Coverage: [Technology Review] [UCSD press release] [Nature Materials - Research Highlight] [Science News]



22. Flores-Merino, M.V., Chirasatitsin, S., LoPresti, C., Reilly, G.C., Battaglia, G., and Engler, A.J. (2010) "Nanoscopic Mechanical Anisotropy in Hydrogel Surfaces" Soft Matter 6(18): 4466-4470 [paper]



21. Chirasatitsin, S. and Engler, A.J. (2010) "Detecting Cell-Adhesive Sites in Extracellular Matrix using Force Spectroscopy Mapping" J Phys: Condensed Matter 22(19): 194102 [paper]



20. Tse, J.R. and Engler, A.J. (2010) "Preparation of Hydrogel Substrates with Tunable Mechanical Properties" Curr Protoc Cell Biol Chapter 10:Unit 10.16: 1-16 [paper]



19. Reilly, G.C. and Engler, A.J. (2010) "Intrinsic Extracellular Matrix Properties Regulate Stem Cell Differentiation" J Biomechanics 43(1): 55-62 [paper]



18. Engler, A.J., Humbert, P.O. Wehrle-Haller, B., and Weaver, V.M. (2009) "Multiscale Modeling of Form and Function" Science 208: 208-212 [paper] Media Coverage: [UCSD Press Release] [Christian Science Monitor]



17. Sen, S., Engler, A.J., and Discher, D.E. (2009) "Matrix Strains Induced by Cells: Computing How Far Cells Can Feel" Cell and Mol Bioeng 2(1): 39-48 [paper]



16. Oh, S., Brammer, K.S., Li, Y.S.J., Teng, D., Engler, A.J., Chien, S., and Jin, S. (2009) "Stem Cell Fate Dictated Solely by Altered Nanotube Dimension" Proc Nat Acad Sci USA 106(7): 2130-2135 [paper] Media Coverage: [UCSD Press Release]



15. Engler, A.J., Chan, M., Boettiger, D., and Schwarzbauer, J.E. (2009) "A Novel Mode of Cell Detachment from Fibrillar Matrix under Shear" J Cell Sci 122(10): 1647-53 [paper] Media Coverage: [F1000 Biology]



14. Williams, C.M., Engler, A.J., Slone, R.D., and Schwarzbauer, J.E. (2008) "Fibronectin Expression Modulates Mammary Epithelial Cell Proliferation During Acinar Differentiation" Cancer Res 68(9): 3185-3192 [paper]



13. Engler, A.J., Carag-Krieger, C., Johnson, C.P., Raab, M., Tang, H.-Y., Speicher, D.W., Sanger, J.W., Sanger, J.M., and Discher, D.E. (2008) "Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating" J Cell Sci 121(22): 3794-3802 [paper]



12. Rehfeldt, F., Engler, A.J., Eckhardt, A., Ahmed, F., and Discher, D.E. (2007) "Cell Responses to the Mechanochemical Microenvironment-Implications for Regenerative Medicine and Drug Delivery" Adv Drug Deliv Rev 59: 1329-1339.



11. Engler, A.J., Sen, S., Sweeney, H.L., and Discher, D.E. (2006) "Matrix Elasticity Directs Stem Cell Lineage Specification" Cell, 126(4): 677-689. [paper] Media Coverage: [CBS News] [Science] [New Scientist] [F1000 Biology] [Research@Penn]



10. Brown, A.G., Leite, R.S., Engler, A.J., Discher, D.E., Strauss, J.F. (2006) "A hemoglobin fragment found in cervicovaginal fluid from women in labor potentiates the action of agents that promote contraction of smooth muscle cells." Peptides, 27(7):1794-800. [paper]



9. Berry, M.F., Engler, A.J., Woo, Y.J, Pirolli, T.J., Bish, L.T., Bell, P., Jayasankar, V., Morine, K.J., Gardner, T.J., Discher, D.E., and H.L. Sweeney (2006) "Mesenchymal Stem Cell Injection After Myocardial Infarction Improves Myocardial Compliance" Am J Physiol: Heart Circ Physiol, 290(6): H2196-H2203. [paper]



8. Dahl, K.N., Engler, A.J., Pajerowski, J.D., and Discher, D.E. (2005) "Power-law rheology of isolated nuclei and mapping deformation of subnuclear domains" Biophysical J, 89(4): 2855-2864. [paper]



7. Zaari, N., Rajagopalan, P., Kim, S.K., Engler, A.J., and Wong, J.Y. (2004) "Hydrogels Photopolymerized in a Microfluidics Gradient Generator: Tuning Substrate Compliance at the Microscale to Control Cell Response" Advanced Materials, 16(23-24): 2133-2137. [paper]



6. Engler, A.J., Griffin, M.A., Sen, S., Bonnemann, C.G., Sweeney, H.L. and Discher, D.E. (2004) "Myotubes Differentiate Optimally on Substrates with Tissue-like Stiffness: Pathological Implications of Stiff and Soft Microenvironments" J Cell Biology, 166(6): 877-887. [paper] Media Coverage: [JCB News and Views] [Nature - Research Highlight]



5. Engler, A.J., Richert, L., Wong, J.Y., Picart, C., and Discher, D.E. (2004) "Surface Probe Measurements of the Elasticity of Sectioned Tissue, Thin Gels and Polyelectrolyte Multilayer Films: Correlations between Substrate Stiffness and Cell Adhesion" Surface Science, 570:142-154. [papers]



4. Richert, L., Engler, A.J., Discher, D.E., and Picart, C. (2004) "Surface Measurement of the Elasticity of Native and Cross-linked Polyelectrolyte Multilayer Films" Biomacromolecules, 5(5): 1908-1916. [paper]



3. Dalhaimer, P., Engler, A.J., Parthasarthy, R., and Discher, D.E. (2004) "Targeted worm micelles" Biomacromolecules, 5(5): 1714-1719.



2. Griffin, M.A., Engler, A.J., Barber, T.A., Healy, K.E., Sweeney, H.L., and Discher, D.E. (2004) "Patterning, Prestress, and Peeling Dynamics of Myocytes" Biophysical J, 86(2): 1209-1222



1. Engler, A.,* Bacakova, L.,* Newman, C., Hategan, A., Griffin, M., and Discher, D. (2004) "Substrate Compliance versus Ligand Density in Cell on Gel Responses." Biophysical J, 86(1): 617-628. *co-first author